Endocrine Abstracts

Introduction: Hypoglycemia is common in people with diabetes who aim to achieve strict glucose control. The neurologic manifestations of hypoglycemia are mostly reversible and includes behavioral changes, difficulty in concentration, confusion, loss of fine motor functions, and seizures. Herein we have presented a case who was pregnant and experienced severe hypoglycemia which led to permanent ataxia.Case: A 26-years-old female patient was brought to our...

While statins which are used safely to treat dyslipidemia, and improve cardiovascular mortality, recent articles claim that they also impairs glycaemic control in type 2 diabetes patients. Meta-analysis of larger scale studies indicate that use of statins is associated with an increase of 9% in diabetes onset. Despite that, we know not much about their effect on glucose regulation in patients already diagnosed with diabetes. Therefore, we aimed to investigate the effect of sta...

Aim: Several studies suggested that there is a relationship between serum levels of IGF1 or their polymorhisms and some cancer types. The genetic polymorphism in the region of IGF promoter region which is composed of cytosine–adenine repeats, affects the promoter activity. It is suggested that serum IGF1 levels are inversely associated with the length of CA repeats. There are studies reporting that the carriers of the CA 19 allele are more likely to develop some cancer ty...

Background: PCOS is one of the most common disorders affecting at least 5–10% of women of reproductive age. Increased prevalance of autoimmune thyroiditis and goiter were reported in PCOS patients. This study investigated the prevalance of hypothyroidism, thyroid autoimmunity, ultrasonographic features and presence of nodules in PCOS patients and compare them with the control group. We also aimed to detect correlation of thyroid volume (TV) with serum IGF1 levels in patie...

Background: Prolactin secreting pituitary adenomas (prolactinomas) is the most common pituitary adenoma. The magnitude of prolactin secretion in prolactinomas is usually proportionate to the tumor’s size. Invasive giant prolactinoma is a large prolactinoma (>4 cm in dimension) presenting with serum prolactin levels of >1000 ng/ml and mass related clinical symptoms. Giant prolactinoma is rare and usually presents in men.Case report: A 52-year...

Case: A 63-year-old acromegalic woman admitted hospital for lassitude and dizziness. She has been diagnosed acromegaly 10 years ago and had two transsphenoidal operations. Remission wasn’t achieved. Then she started to use lanreotide (somatostatin analogue) and for 7 years she has been treated with it. In laboratory examination, basal plasma GH 1.21 ng/ml (NR:0–5); nadir GH level after glucose tolerance test, 1.2 ng/ml (NR: less than 1); IGF1, 129.1 ng/ml (NR: for ag...

Background: Hypogonadism is related to additional endocrine abnormalities. Thyroid abnormalities may be common in hypogonadism patients, although this association is not clear.Objective: In this study, we examined the incidence of thyroid disorders in hypogonadisms.Methods: A case–control study of 68 hypogonadal patients and 74 age-matched healthy controls from the general population was conducted. Thyroid function, thyroid vo...

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder that is characterized by hypercalcemia and elevated or normal levels of parathyroid hormone (PTH). Most PHPT cases are incidentally discovered when routine laboratory analysis reveals hypercalcemia. PHPT should be considered in any person with elevated serum calcium (Ca) levels and no clear evidence of malignancy. Serum phosphorus (P) is low due to the phosphaturic effects of PTH and mostly in the ...

Introduction: Dopamine agonists (DAs) consisting of cabergoline (CAB) or bromocriptine is the primary therapy in prolactinomas. DAs are also used in Parkinson’s disease and restless leg syndrome with much higher doses. As a result of reports related to doses in these patients, it is known that long term use of DAs can lead to fibrotic syndromes affecting heart and lung. Cardiac valvulopathies are the most common investigated side effects but there are case reports of ple...

Introduction: Metastatic pituitary tumors are seen rarely and it is hard to differentiate them from the benign lesions of the gland. We have reported a case, with a known maxillary sinus tumor, detected to have a pituitary lesion coincidentally on PET-CT.Case: 45 years old male patient with a known history of relapsed maxillary sinus tumor has been referred to our clinics because of the pituitary lesion detected to have increased FDG involvement on PET-C...